|(iv)||Shared power to dispose or to direct the disposition of|
See Cover Pages Items 5-9.
|Item 5.||Ownership of Five Percent or Less of a Class.|
|Item 6.||Ownership of More than Five Percent on Behalf of Another Person.|
Partners, BVF Inc. and Mr. Lampert share voting and dispositive
power over the shares of Common Stock beneficially owned by BVF, BVF2 and the Partners Managed Accounts.
|Item 7.||Identification and Classification of the Subsidiary That Acquired the Security Being Reported on by the Parent Holding Company
or Control Person.|
|Item 8.||Identification and Classification of Members of the Group.|
See Exhibit 99.1 to the Schedule 13G filed with the Securities
and Exchange Commission on July 19, 2016.
|Item 9.||Notice of Dissolution of Group.|
By signing below each of the undersigned certifies
that, to the best of its knowledge and belief, the securities referred to above were not acquired and are not held for the purpose
of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not
held in connection with or as a participant in any transaction having that purpose or effect.