OREXIGEN THERAPEUTICS, INC.
CERTIFICATE OF AMENDMENT OF BYLAWS
The undersigned hereby certifies that he or she is the duly elected, qualified, and acting
Secretary or Assistant Secretary of Orexigen Therapeutics, Inc., a Delaware corporation and that
the foregoing bylaws, comprising seventeen pages, were amended and restated on ___, 2007
by the corporations board of directors.
WITNESS WHEREOF, the undersigned has hereunto set his or her hand this ___ day of