CERTAIN MATERIAL (INDICATED BY AN ASTERISK) HAS BEEN OMITTED FROM THIS DOCUMENT PURSUANT
TO A REQUEST FOR CONFIDENTIAL TREATMENT. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY
WITH THE SECURITIES AND EXCHANGE COMMISSION.
Orexigen Therapeutics, Inc.
One Palmer Square, Suite 515
Princeton, NJ 08542
February ___, 2004
Lee G. Dante, M.D.
[***], [***] [***]
Dear Dr. Dante:
The purpose of this letter agreement (the Agreement) is to set forth the principal terms of
the agreement that we have reached with respect to your rendering of consulting and advisory
services to Orexigen Therapeutics, Inc. (Orexigen) with respect to Orexigens efforts to develop
one or more products for appetite control, control of food intake and/or obesity treatment. That
agreement is as follows:
At times agreeable to you and as requested by Orexigen, you will make available your services
and consult with Orexigen with respect to Orexigens efforts to develop one or more products for
appetite control, control of food intake and/or obesity treatment and such other matters as may be
agreed upon between Orexigen and you. It is anticipated that you will spend approximately ___days
per month in rendering services pursuant to the terms hereof.
2. Compensation and Related Matters.
(a) As compensation for services rendered pursuant to the terms of this Agreement, Orexigen
shall pay you [***] Dollars ($[***]) per month.
(b) You shall be reimbursed for out-of-pocket expenses incurred by you in connection with the
rendering of services pursuant to the terms hereof, including all reasonable expenses for air
travel necessary and requested by Orexigen, and all reasonable living expenses incurred by you when
rendering services for Orexigen at locations away from your home or business. We request that any
single expense in excess of [***] Dollars ($[***]) be approved by Orexigen in advance. To
facilitate reimbursement, you agree to provide, on a monthly basis, Orexigen with an invoice
itemizing your travel and other expenses,
together with receipts evidencing such expenses, and Orexigen shall make a reimbursement payable to
you within [***] ([***]) days of receipt of such invoice
||Certain information on this page has been omitted and filed separately
with the Commission. Confidential treatment has been requested with respect to the omitted portions.