OREXIGEN THERAPEUTICS, INC.
l Shares of Common Stock
(Par Value $0.001 Per Share)
1. The initial public offering price per share for the Securities, determined as provided in said
Section 2, shall be $l.
2. The purchase price per share for the Securities to be paid by the several Underwriters shall be
$l, being an amount equal to the initial public offering price set forth above less $l
per share; provided that the purchase price per share for any Option Securities purchased upon the
exercise of the overallotment option described in Section 2(b) shall be reduced by an amount per
share equal to any dividends or distributions declared by the Company and payable on the Initial
Securities but not payable on the Option Securities.