INFORMATION REQUIRED IN REGISTRATION STATEMENT
Item 1. Description of Registrants Securities to be Registered.
A description of the Common Stock, par value $0.001 per share (Common Stock), of Orexigen
Therapeutics, Inc., a Delaware corporation (the Registrant), to be registered hereunder is
contained under the caption Description of Capital Stock in the Prospectus that constitutes part
of the Registrants Registration Statement on Form S-1 (File No. 333-139496) initially filed with
the Securities and Exchange Commission on December 19, 2006, as amended from time to time, and is
incorporated herein by reference.
Item 2. Exhibits.
Under the Instructions as to Exhibits with respect to Form 8-A, no exhibits are required
to be filed, because no other securities of the Registrant are registered on The NASDAQ Stock
Market LLC and the securities registered hereby are not being registered pursuant to Section
12(g) of the Securities Exchange Act of 1934, as amended.