Certificate of Amendment
Amended and Restated Certificate of Incorporation
Orexigen Therapeutics, Inc.,
a Delaware corporation
Orexigen Therapeutics, Inc., a corporation organized and existing under the laws of
the State of Delaware (the Corporation), hereby certifies as follows:
1. That the Board of Directors (the Board) of said Corporation duly adopted a resolution
proposing and declaring advisable the following amendment of the Amended and Restated Certificate
of Incorporation (the Certificate) of said Corporation. The resolution setting forth the
proposed amendment is as follows:
RESOLVED, that the Certificate be amended by adding the following paragraphs after Section A
of Article IV, prior to Section B of Article IV:
Effective upon the filing of this Certificate of Amendment with the Secretary of State of the
State of Delaware, a 1-for-2 reverse stock split for each share of Common Stock outstanding or held
in treasury immediately prior to such time shall automatically and without any action of the part
of the holders thereof occur (the Reverse Stock Split). The par value of the Common Stock shall
remain $0.001 per share. This conversion
shall apply to all shares of Common Stock. No fractional
shares of Common Stock shall be issued upon the Reverse Stock Split or otherwise. In lieu of any
fractional shares of Common Stock to which the stockholder would otherwise be entitled upon the
Reverse Stock Split, the Corporation shall pay cash equal to such fraction multiplied by the then
fair market value of the Common Stock as determined by the Board of Directors.
All certificates representing shares of Common Stock outstanding immediately prior to the
filing of this Certificate of Amendment shall immediately after the filing of this Certificate of
Amendment represent instead the number of shares of Common Stock as provided above.
Notwithstanding the foregoing, any holder of Common Stock may (but shall not be required to)
surrender his, her or its stock certificate or certificates to the corporation, and upon such
surrender the corporation will issue a certificate for the correct number of shares of Common Stock
to which the holder is entitled under the provisions of this Certificate of Amendment. Shares of
Common Stock that were outstanding prior to the filing of this Certificate of Amendment, and that
are not outstanding after and as a result of the filing of this Certificate of Amendment, shall
resume the status of authorized but unissued shares of Common Stock.
2. That thereafter, pursuant to resolution of the Board and in lieu of a meeting of
stockholders, the stockholders gave their approval of said amendment by written consent in
accordance with the provisions of Section 228 of the General Corporation Law of the State of
3. That the aforesaid amendment was duly adopted in accordance with the provisions of Sections
242 and 228 of the General Corporation Law of the State of Delaware.
4. That said amendment shall be executed, filed and recorded in accordance with Section 103 of
the General Corporation Law of the State of Delaware.
IN WITNESS WHEREOF, Orexigen Therapeutics, Inc. has caused this Certificate of Amendment to be
signed by an authorized officer thereof, this 6th day of April, 2007.
||Orexigen Therapeutics, Inc.
||/s/ Gary D. Tollefson
||Gary D. Tollefson, M.D., Ph.D.
||President and Chief Executive Officer